Efficacy and safety of amiodarone on the treatment of ventricular arrythmia in Uygur patients with organic heart disease

Objective: To evaluate the efficacy and safety of amiodarone in the treatment of ventricular arrythmia in Uygur patients with organic heart disease. Methods:47 patients with ventricular arrythmia and organic heart disease were treated with amiodarone and followed up 1-3 years. Result: Intravenous loading dose of 3-5 mg/kg amiodarone was given within 10 minutes, followed by 1-1.5 mg/min infusion. The administration of amiodarone was effective in 6 patients with recurrent sustained ventricular tachycardia and/or fibrillation. Oral maintenance amiodarone dose of 200 mg/d could control ventricular arrythmia (92. 7%). There were sinus bradycardia (5/6), long PR (1/6) in intravenous amiodarone patients. There were low thyroid function(l/41) , sinus bradycardia (18/41), long QT (22/41), but no pulmonary toxicity in oral maintenance amiodarone patients. Conclusions: Amiodarone has high efficacy and relative safe for treatment of ventricular arrythmia in Uygur patients with organic heart disease.