Study of effect and security of amiodarone on treating severe arrhythmia with acute coronary syndrome

Objective To evaluate the efficiency and the safety of amiodarone for the treatment of atrial fibrillation with rapid ventricular response,atrial flutter with rapid ventricular response,or ventricular arrhythmia in patients with acute coronary syndrome(ACS).Methods112 patients with the diseases mentioned above treated in our hospital were selected as the study objects.The first bolus of 150 mg amiodarone was given intravenously,repeated with the same dose if no efficacy shown.Later intravenous drip was given by 1.0 mg/min in 6 h,and then by 0.5/min.The total dosage was 1050-1500 mg.Then oral amiodarone was given 600 mg/d the first week,400 mg/d the second,200 mg/d the third and the forth.Results100 cases were effective in 0.5~24 h.ConclusionIntravenous and oral amiodarone is secure and effective in the treatment of atrial fibrillation with rapid ventricular response,atrial flutter with rapid ventricular response,or ventricular arrhythmia in patients with acute coronary syndrome.