ScholarLens Back to search
2002•Zhongguo linchuang yaolixue yu zhiliaoxueRequires access

Study on a HPLC method of determination of nifedipine content

Zhu Bi

Open publisher page 0 citations

Abstract

AIM: To establish a HPLC method to determine nifedopine the content and uniformity of nifedopine tablet. METHODS: HPLC condition was set as ODS column, flow phase: methanol water (6040), flow rate: 0.8 ml·min -1 , and detection wavelength: 235 nm. RESULTS: The nifedopine linear range was 0.020-0.200 g·L -1 in this method. The average recovery rates were 99.6%, 98.9%, and 100.4% in high, normal and low concentrations, respectively. The corresponding values of RSD were 0.42%, 0.54% and 0.35% (n=5). CONCLUSION: This HPLC method shows a high specificity and sensitivity, and is accurate, simple and rapid in performance.

About this research paper

What this paper is about

AIM: To establish a HPLC method to determine nifedopine the content and uniformity of nifedopine tablet. METHODS: HPLC condition was set as ODS column, flow phase: methanol water (6040), flow rate: 0.8 ml·min -1 , and detection wavelength: 235 nm. RESULTS: The nifedopine linear range was 0.020-0.200 g·L -1 in this method. The average recovery rates were 99.6%, 98.9%, and 100.4% in high, normal and low concentrations, respectively. The corresponding values of RSD were 0.42%, 0.54% and 0.35% (n=5). CONCLUSION: This HPLC method shows a high specificity and sensitivity, and is accurate, simple and rapid in performance.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

AIM: To establish a HPLC method to determine nifedopine the content and uniformity of nifedopine tablet. METHODS: HPLC condition was set as ODS column, flow phase: methanol water (6040), flow rate: 0.8 ml·min -1 , and detection wavelength: 235 nm. RESULTS: The nifedopine linear range was 0.020-0.200 g·L -1 in this method. The average recovery rates were 99.6%, 98.9%, and 100.4% in high, normal and low concentrations, respectively. The corresponding values of RSD were 0.42%, 0.54% and 0.35% (n=5). CONCLUSION: This HPLC method shows a high specificity and sensitivity, and is accurate, simple and rapid in performance.

Key concepts: High-performance liquid chromatography, Chromatography, Nifedipine, Content determination, Linear range, Chemistry, Methanol, Volumetric flow rate

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Study on a HPLC method of determination of nifedipine content — Research Paper | ScholarLens