A DETECTION OF PLASMA ADRENOMEDULLIN ENDOTHELIN-1, AND VON WILLEBRAND FACTOR IN PATIENTS WITH HYPERTENSION

Objective To study the relationship between the risk stratification in essential hypertension(EH) and the levels of plasma VWF, ADM and ET 1, and explore the clinic significance. Methods Eighty EH patients with different risk stratification were randomly selected for this study. The plasma VWF,ADM and ET 1 were detected and compared with 20 normal controls. Results Before treatment ,the levels of plasma VWF, ET 1, ADM increased significantly in EH group compared to that of the control group, the difference was significant ( F=6.23-17.08, q=4.27-10.43, P 0.05), and the levels of VWF, ET 1 And ADM elevated with the increase of the risk ( q=3.87-6.86, P 0.05). The levels of ADM, ET 1 and VWF were lower than that of before treatment, the difference showed great difference ( t= 3.71-20.8, P 0.05). Conclusion ADM, ET 1 and VWF are involved in the occurrence and development of essential hypertension. Proper therapy can lower the levels of ET 1, ADM and VWF.