Relationship Between Plasma Endothelin1, Nitric Oxide and von Willebrand Factor and Diabetic Retinopathy

Objective To detect the relationship between the endothelial markers of plasma endothelin1(ET-1),NO and von Willebrand(vWF) and the severity of diabetic retinopathy.Methods 85 patients diagnosed with type 2 diabetes by the WHO standard with or without diabetic retinopathy(DR),and 30 normal controls were selected.Plasma ET-1 and vWF levels were measured by enzyme-linked immunosorbent assay,NO levels were measured by nitrate reductase method,and hemoglobin A_(1C)(HbA_(1C)) was measured by ion exchange chromatospectrophotometry,the correlated index of biochemistry and clinic were recorded.Results ET-1,NO and vWF levels significantly increased in plasma of type 2 diabetes with or without DR as compared to the control group(P0.01).ET-1 levels were correlated with sBP, dBP and course positively,significantly positively with fasting plasma glucose(FPG),HbA_(1C),vWF levels,NO levels were correlated with course positively,vWF levels were correlated with ET-1,course,FPG,HbA_(1C) positively and negatively with NO levels.Conclusions The development of DR might be related to the rank of endothelial dysfunction.