Clinical study of venlafaxine combined with quetiapine in the treatment of anxiety disorder

Objective To investigate the efficacy and safety of venlafaxine combined with Quetiapine in the treatment of anxiety disorder.Methods 60 patients were randomly divided into 6 weeks of quetiapine combined releasing venlafaxine or releasing venlafaxine monotherapy group.The efficacy and adverse effect of the two groups were accessed by Hamilton anxiety scale(HAMA)and treatment emergent symptom scale(TESS)before and l weeks,2 weeks,4 weeks,6 weeks after the treatment.Results There were significant differences of the total score and deducted scores of HAMA between two groups by the end of 2 weeks,4 weeks and 6 weeks.The recovery rate and the effective rate between groups performed significant differences.No significant difference of adverse effects was found in the two groups.Conclusion The effect of venlafaxine combined with quetiapine is better than venlafaxine alone in treatment of anxiety disorder.