Effect of different doses of Clopidogrel on platelet aggregation rate in the patients with percutaneous coronary intervention

Objective To investigate the platelet aggregation effects with different doses of clopidogrel in the patients after percutaneous coronary intervention(PCI).Methods Blood samples obtained from 118 patients after PCI were randomized to double-blind treatment with clopidogrel 600mg loading dose(LD),group A(n=60)with clopidogrel 75mg maintance dose(MD)and group B(n=58)with clopidogrel 150mg maintenance dose(MD).Maximal platelet aggregation rate was measured before PCI and after 1,7,14 and 30 days of PCI.Results There were no significant differences in max% induced by ADP between two groups before PCI and 1 day after PCI,whereas there were significantly decreased platelet aggregation rate in group B(P0.01)at 7,14 and 30 days after PCI.Conclusion This finding proved that a dose of clopidogrel(150 mg/d)can improve platelet aggregation function in patients after PCI.