Effects of different doses clopidogrel on platelet aggregation and hs-CRP levels in patients with acute myocardial infarction after PCI treatment

Objective:To investigate the effects of different doses of clopidogrel on platelet aggregation and hs-CRP levels in patients with acute myocardial infarction after PCI.Methods:A total of 80patients with acute ST-segment elevation myocardial infarction(STEMI)were randomly divided into two groups,both groups were given clopidogrel 300mg + aspirin 300mg before undergoing PCI,and the high-dose group were given clopidogrel 150mg/d(and 75mg/d 7days later),the standard-dose group were given 75mg/d after undergoing PCI.End-point events,the platelet aggregation,serum hs-CRP levels and clinical endpoints were compared between the two groups.Results:The platelet aggregation and serum hs-CRP levels were significantly decreased after undergoing PCI,but these indicators in the highdose group were significantly lower than that of the standard-dose group(P0.05).There were no significant difference in incidence of combined endpoint events and bleeding events between the two groups(P0.05).Conclusion:Patients with STEMI after undergoing PCI maintained with high maintenance dose of clopidogrel can reduce platelet aggregation and reduce the inflammatory response comparing with standard dose treatment.