2011•TumoriRequires access
Clinical significance of serum nidogen-2 and carbohydrate antigen 125 in patients with ovarian serous cystadenocarcinoma
Yan Chen, Ping Jin, Hong-xiu Zhang, Lan-sheng Yang, Ying Feng
Open publisher page 1 citations
Abstract
Objective: To evaluate the clinical significance of serum nidogen-2 and carbohydrate antigen 125 (CA125) in patients with ovarian serous carcinoma. Methods: The serum levels of nidogen-2 and CA125 were determined by ELISA and chemiluminescent assay in 15 cases of normal ovary, 22 cases of ovarian serous cystadenoma, and 40 cases of ovarian serous cystadenocarcinoma. Results: Compared with the normal ovary and ovarian serous cystadenoma, the serum level of nidogen-2 was higher in cases of ovarian serous cystadenocarcinoma (P ＜0.05). The difference of serum nidogen-2 level between the cases of normal ovary and ovarian serous cystadenoma was not significant. The cases of ovarian serous cystadenocarcinoma at Ⅲ-Ⅳ stages had a higher serum nidogen-2 level than those at Ⅰ-Ⅱ stages (P ＜0.05). The diagnostic sensitivity and specificity were both improved by combined detection of serum nidogen-2 and CA125. Conclusion: Serum nidogen-2 can be used as a new biomarker for ovarian serous cystadenocarcinoma. DOI:10.3781/j.issn.1000-7431.2011.04.011