Effect of hydrotalcid combined with Tibolone on the bile reflux gastritis and intragastric bile in the menopause patients with bilereflux gastritis

Objective:To evaluate the effect of hydrotalcid combined with Tibolone,a compound with the effects of estrogen,progestogen and androgen on the menopause patients with bile-reflux gastritis and 24-hour intragastric bile.Methods:Nineteen menopause women with bile-reflux gastritis proven by gastroscope and 24-hour intragastric bile monitoring were divided into 2 groups at random, which were treated with hydtotalcid 1.0g three times a day and the same dose of hydrotalcid combined with Tibolone 2.5mg one time a day.The severity of the symptoms including heartburn,epigastric distention,nausea and bile vomiting was investigated before and after 2,4 weeks treatment.Twenty-four hour intragastrie bile monitoring was also reexamined.Results:The severity of all the symptoms in the two groups decreased greatly after 2 weeks treatment.After 4 weeks treatment,the severity of all the symptoms decreased further.The total fraction time of bile reflux,the time of the longest bile reflux in two groups decreased greatly after treatment ( P 0.05).Conclusion:Hydrotalcid combined with Tibolone can release the symptoms of bile reflux gastritis of menopause women with functional dyspepsia and decreased the index of 24 hour intragastric bile monitcring,and it is an effectire treatment program for the menopause women with bile reflux gastritis.