Association of Vascular Endothelial Growth Factor Expression With Micro vessel Density and Proliferating Cell Nuclear Antigen In Non-Small Cell Lung Cancer

Objective:To evaluate the expression of vascular endothelial growth factor (VEGF),microvessl density (MVD) and Proliferating Cell Nuclear Antigen (PCNA) in Non-Small Cell Lung Cancer (NSCLC) and inv estigate its relationship to histopathological features.Methods:The expression of VEGF and PCNA was evaluated in 59 specimens of NSCLC by immunohistochemistry,a monoclonal antibody directed against CD34 to identify MVD.Results:the positive rate of VEGF was 64.4%(38/59).The expression of VEGF was related to pathological grade and survival time.The difference was significant among the groups (P0.05).The expression of VEGF have no significant relationship with some pathological characteristics such as histological types,TNM classification and lymph nodes metastasis.The positive rate of PCNA was 61.0%(36/59).The expression of PCNA was related to pathological grade and survival time.The difference was significant (P0.05).MVD varied from 3 to 20(M=9).Conclusion:VEGF,MVD and PCNA may be used as a hopeful marker for predicting the metastasis potential of non-small cell lung cancer and t he prognosis of these patients.