Expression of VEGF and PCNA in lung cancer and its relationship with prognosis

Objective To explore the expression of VEGF and PCNA in lung cancer and its relationship with prognosis.Methods Selected 70 cases of lung cancer as experience group and 60 healthy peason as control.Immunochistochemical method was used to detect the expression of VEGF and PCNA in lung cancer tissues and normal lung tissue.Results The positive rate of VEGF were 67.1% and 35.0% in experience group and control group respectively(P0.01);The positive of PCNA in experience group was much higher than in control group(74.3% vs 15.0%,P0.01);Eexpression of VEGF was related to lymph node metastasis and clinical stages(P0.01).The expression of PCNA was significantly associated with lymph node metastasis,clinical stages and histological differentiation(P0.01).The 5 year survival rate in high VEGF expression patients was much lower than in low VEGF expression cases(6.4% vs 21.7%,P0.01);The 5 year survival rates were 7.7% and 22.2% in high PCNA expression and low PCNA expression patients with significant difference(P0.01).Conclusions High expression of VEGF and PCNA are closely related to the occurrence and biological behavior of lung cancer.Detection of VEGF and PCNA can be important indexes for evaluating the prognosis of lung cancer.