Clinical study of combination therapy with doxazosin and tolterodine for patients with overactive bladder after transurethral resection of the prostate

Objective To evaluate the efficacy of combination therapy with doxazosin and tolterodine for patients with overactive bladder(OAB) after transurethral resection of the prostate(TURP).Methods Totally 86 patients with OAB after TURP were randomly divided into doxazosin group(n=46) and combination group(n=40).The patients in doxazosin group were administered with doxazosin extended release(ER) table(4 mg once daily),and those in combination group were administered with doxazosin and tolterodine ER tablet(4 mg once daily for each).The international prostate symptom score(IPSS),overactive bladder symptom score(OABSS) and adverse reactions were recorded.Results The values of IPSS and Qmax were significantly improved after treatment(P0.05) in doxazosin group.The values of IPSS,storage IPSS,OABSS,3rd score of OABSS and Qmax were also significantly improved after treatment(P0.05)in the combination group.While the reduction of IPSS,storage IPSS,OABSS and 3rd score of OABSS in combination group was significantly greater than those in doxazosin group(P0.01).Conclusion It is effective and safe for patients with OAB after TURP to accept the combination therapy with doxazosin and tolterodine ER tablets.