Doxazosin combined with Tolterodine Tartrate in the treatment of benign prostatic hyperplasia with overactive bladder

Objective To evaluate Doxazosin and Tolterodine Tartrate in the treatment of patients with benign prostatic hyperplasia(BPH)with overactive bladder(OAB).Methods 167 patients suffering from BPH and OAB were randomly divided into two groups,one group treated with Doxazosin and Tolterodine Tartrate,the other group were treated with Doxazosin only.The effects were evaluated with IPSS,QOL,maximum flow rate.average flow rate,voiding volume,urgency rating scale(before treatment,1 weeks,6weeks and 12 weeks after treatment).Results All parameter were significantly improved in both group.The patients in Doxazosin plus Tolterodine Tartrate groups reported treatment enefit than Doxazosin monotherapy group in QOL and urgency rating scale,and postvoid residual volume has no difference.Conclusion Doxazosin plus Tolterodine Tartrate is a effective and safety therapeutic method for patients with BPH and OAB.