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2012•Chinese Journal of New Drugs and Clinical RemediesRequires access

Study on absolute bioavailability of liguzinediol in rats

Huimin Bian

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Abstract

AIM To study the pharmacokinetics characteristics of liguzinediol and its absolute bioavailability in rat.METHODS The plasma from 36 SD rats(half male and half female) with intragastric and intravenous administration were collected in different time point.The plasma concentration of liguzinediol was determined by UPLC.The pharmacokinetic parameters and absolute bioavailability were calculated by DAS 2.0 software.RESULTS The AUC_(0-∞) showed linear-relation after intragastric(50,20,10 mg·~kg~(-1)) and intravenous(20,10,5 mg·kg~(-1)) administration.And the absolute bioavailability was higher than 90%. CONCLUSION The pharmacokinetic study shows that liguzinediol is characterized with good oral absorption capacity,short eliminate half - life,and linear pharmacokinetics,suggesting that its pharmacokinetic performances are appropriate and merit further development.

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AIM To study the pharmacokinetics characteristics of liguzinediol and its absolute bioavailability in rat.METHODS The plasma from 36 SD rats(half male and half female) with intragastric and intravenous administration were collected in different time point.The plasma concentration of liguzinediol was determined by UPLC.The pharmacokinetic parameters and absolute bioavailability were calculated by DAS 2.0 software.RESULTS The AUC_(0-∞) showed linear-relation after intragastric(50,20,10 mg·~kg~(-1)) and intravenous(20,10,5 mg·kg~(-1)) administration.And the absolute bioavailability was higher than 90%. CONCLUSION The pharmacokinetic study shows that liguzinediol is characterized with good oral absorption capacity,short eliminate half - life,and linear pharmacokinetics,suggesting that its pharmacokinetic performances are appropriate and merit further development.

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Available abstract

AIM To study the pharmacokinetics characteristics of liguzinediol and its absolute bioavailability in rat.METHODS The plasma from 36 SD rats(half male and half female) with intragastric and intravenous administration were collected in different time point.The plasma concentration of liguzinediol was determined by UPLC.The pharmacokinetic parameters and absolute bioavailability were calculated by DAS 2.0 software.RESULTS The AUC_(0-∞) showed linear-relation after intragastric(50,20,10 mg·~kg~(-1)) and intravenous(20,10,5 mg·kg~(-1)) administration.And the absolute bioavailability was higher than 90%. CONCLUSION The pharmacokinetic study shows that liguzinediol is characterized with good oral absorption capacity,short eliminate half - life,and linear pharmacokinetics,suggesting that its pharmacokinetic performances are appropriate and merit further development.

Key concepts: Bioavailability, Pharmacokinetics, Pharmacology, Absorption (acoustics), Oral administration, Plasma concentration, Chemistry, Half-life

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