Experimental observation on the germicidal efficacy and toxicity of fluid peracetic acid disinfectant.

Objective To understand the germicidal efficacy and toxicity of fluid peracetic acid disinfectant. Methods Suspension quantitative germicidal test and toxicity test were carried out for laboratory observation. Results The peracetic acid content decreased by 1.09% five months after the fluid peracetic acid disinfectant stored in unified package at room temperature. The killing logarithm of E.coli and Staphylococcus aureus of suspension exposed to the solution containing 244mg/L peracetic acid and 5 min was 5.00., and that of B.subtilis var. niger spores exposed to the solution containing 2 440mg/L peracetic acid was 5.00. The average killing logarithm, food industry conduit soaked with the solution containing 244mg/L peracetic acid 5 min and xylon tabletop soaked with the solution containing 2 440mg/L peracetic acid 10 min, was 5.84 and 3.23, respectively. The oral LD_ 50 for mice of stock solution containing peracetic acid was 584mg/kg.bw and the toxicity of this stock solution was low. The oral LD50 for mice with 5 fold concentration of stock solution was 5 000mg/kg.bw. It belongs to practically non-toxic class and was not irritative to skin. The mouse bone marrow polychromatic erythrocyte micronucleus test was negative. There are no caustic for stainless steel, middle-class caustic for mild steel, and high-class caustic for aluminium and copper after soaked for a duration of 72 hours with solution containing 2 440mg/L of peracetic acid. Conclusion The disinfectant is chemically stable and show excellent germicidal efficacy and low toxicity.