Study on the Preparation Technology of Aspirin-chitosan Sustained Release Mincrocapsule and the Aspirin Microcapsule's Release

A complex coacervation method was used to prepare aspirin microcapsule using chitosan and Gum-arabic as the wall materials.The orthogonal experimental design using the standard of drug encapsulation was applied to optimize the preparation procedure of the microcapsules.The result show that pH=4.5C,(chitosan)=0.6%,v=200r·min~(-1),T=60℃ are the best technology.The vitro release of the microcapsules indicate that these microcapsules may prove better sustained release of drugs.