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Study on the Preparation Technology of Ibuprofen-chitosanSustained Release Microcapsule

Yushu Liu

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Abstract

A complex coacervation method was used to prepare Ibuprofen microcapsule using chitosan and Gum-arabic as the wall materials .The orthogonal experimental design using the standard of drug encapsulation was applied to optimize the preparation procedure of the microcapsules.The result show that pH=4.5,C(chitosan )=0.2 %,v=200 rpm,T=45 ℃ are the best technology.The vitro release of the microcapsules indicate that these microcapsules may prove better sustained release of drugs.

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What this paper is about

A complex coacervation method was used to prepare Ibuprofen microcapsule using chitosan and Gum-arabic as the wall materials .The orthogonal experimental design using the standard of drug encapsulation was applied to optimize the preparation procedure of the microcapsules.The result show that pH=4.5,C(chitosan )=0.2 %,v=200 rpm,T=45 ℃ are the best technology.The vitro release of the microcapsules indicate that these microcapsules may prove better sustained release of drugs.

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Available abstract

A complex coacervation method was used to prepare Ibuprofen microcapsule using chitosan and Gum-arabic as the wall materials .The orthogonal experimental design using the standard of drug encapsulation was applied to optimize the preparation procedure of the microcapsules.The result show that pH=4.5,C(chitosan )=0.2 %,v=200 rpm,T=45 ℃ are the best technology.The vitro release of the microcapsules indicate that these microcapsules may prove better sustained release of drugs.

Key concepts: Coacervate, Ibuprofen, Chitosan, Gum arabic, Arabic, Chemistry, Chromatography, Materials science

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