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Alteration of inflammatory cytokines of severe acute pancreatitis and therapeutic effects of verapamil

Chen You-da

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Abstract

Objective To evaluate the alteration of inflammatory cytokine during sere acute pancreatitis(SAP) and the therapeutic effects of verapamil in rats.Methods A total of 90 SD male rats were randomly divided into Group A(sham-operative group),Group B(SAP group) and Group C(SAP treated with verapamil).The model of rat SAP induced by amend Aho's converse pancreas bile duct puncture injection.All rats were killed at 6 hours after operation.Blood samples were taken for measurement of IL-1,IL-6 and TNF-.Results In SAP group the levels of IL-1,IL-6 and TNF-were significantly increased compared with those of sham-operative group(0.01).In SAP with verapamil therapy group,the levels of IL-1,IL-6 and TNF-in serumwere significantly lower than those of SAP group(0.05 or 0.01).Conclusion Inflmanatory cytokines,IL-1,IL-6 and TNF-are increased remarkably in SAP.Verapamil can reduce the level of serum IL-1,IL-6 and TNF-and the dam-age to pancreatic tissue.

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Objective To evaluate the alteration of inflammatory cytokine during sere acute pancreatitis(SAP) and the therapeutic effects of verapamil in rats.Methods A total of 90 SD male rats were randomly divided into Group A(sham-operative group),Group B(SAP group) and Group C(SAP treated with verapamil).The model of rat SAP induced by amend Aho's converse pancreas bile duct puncture injection.All rats were killed at 6 hours after operation.Blood samples were taken for measurement of IL-1,IL-6 and TNF-.Results In SAP group the levels of IL-1,IL-6 and TNF-were significantly increased compared with those of sham-operative group(0.01).In SAP with verapamil therapy group,the levels of IL-1,IL-6 and TNF-in serumwere significantly lower than those of SAP group(0.05 or 0.01).Conclusion Inflmanatory cytokines,IL-1,IL-6 and TNF-are increased remarkably in SAP.Verapamil can reduce the level of serum IL-1,IL-6 and TNF-and the dam-age to pancreatic tissue.

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Available abstract

Objective To evaluate the alteration of inflammatory cytokine during sere acute pancreatitis(SAP) and the therapeutic effects of verapamil in rats.Methods A total of 90 SD male rats were randomly divided into Group A(sham-operative group),Group B(SAP group) and Group C(SAP treated with verapamil).The model of rat SAP induced by amend Aho's converse pancreas bile duct puncture injection.All rats were killed at 6 hours after operation.Blood samples were taken for measurement of IL-1,IL-6 and TNF-.Results In SAP group the levels of IL-1,IL-6 and TNF-were significantly increased compared with those of sham-operative group(0.01).In SAP with verapamil therapy group,the levels of IL-1,IL-6 and TNF-in serumwere significantly lower than those of SAP group(0.05 or 0.01).Conclusion Inflmanatory cytokines,IL-1,IL-6 and TNF-are increased remarkably in SAP.Verapamil can reduce the level of serum IL-1,IL-6 and TNF-and the dam-age to pancreatic tissue.

Key concepts: Verapamil, Acute pancreatitis, Medicine, Cytokine, Pancreatitis, Internal medicine, Therapeutic effect, Tumor necrosis factor alpha

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