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Preparation and Antibacterial Activity of Water-soluble O-Carboxymethyl Chitosan Quaternary Ammonium Salt

XU Ben-jin

Abstract

Objective: To prepare and structurally characterize water-soluble O-carboxymethyl chitosan quaternary ammonium salt(CMCQAS),and to evaluate its antibacterial activity.Method: The preparation of water-soluble CMCQAS was conducted by using 3-chloro-2-hydroxypropyl trimethyl ammonium chloride(CTA) and chloroacetic acid as grafting agents.Its structure was characterized by IR and ultraviolet spectroscopy and its antibacterial activitiy against S.aureus,E.coli and A.niger were evaluated.Results: The prepared water-soluble CMCQAS had a distinct antibacterial activity against S.aureus,E.coli and A.niger,which was higher than that of chitosan(CS).

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Key concepts: Chitosan, Antibacterial activity, Chloroacetic acid, Chemistry, Ammonium, Nuclear chemistry, Salt (chemistry), Grafting