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2008•Acta Academiae Medicinae WeifangRequires access

A Primary Study of Loss of Heterozygosity on Chromosome 1p36 in Glioblastomas

Hui Wang

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Abstract

Objective The study of loss of heterozygosity(LOH) was performed to locate the deletion areas probably harboring tumor suppressor genes and provide clues for discovering tumor suppressor genes.Methods Twelve polymorphic microsatellite markers on chromosome 1p36 in 12 cases of glioblastomas were analyzed to detect LOH by PCR based techniques.Results 91.7% informative cases of Glioblastomas displayed LOH on 1p36.The most frequent LOH were observed at loci from D1S214 to D1S2666 on 1p36.Conclusion The highly frequent LOH was observed on chromosome 1p36 in human Glioblastomas.The results of this study indicate that the chromosomal regions at loci from D1S214 to D1S2666 on 1p36 may contain tumor suppressor genes associated with the origin of Glioblastomas.

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Objective The study of loss of heterozygosity(LOH) was performed to locate the deletion areas probably harboring tumor suppressor genes and provide clues for discovering tumor suppressor genes.Methods Twelve polymorphic microsatellite markers on chromosome 1p36 in 12 cases of glioblastomas were analyzed to detect LOH by PCR based techniques.Results 91.7% informative cases of Glioblastomas displayed LOH on 1p36.The most frequent LOH were observed at loci from D1S214 to D1S2666 on 1p36.Conclusion The highly frequent LOH was observed on chromosome 1p36 in human Glioblastomas.The results of this study indicate that the chromosomal regions at loci from D1S214 to D1S2666 on 1p36 may contain tumor suppressor genes associated with the origin of Glioblastomas.

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Available abstract

Objective The study of loss of heterozygosity(LOH) was performed to locate the deletion areas probably harboring tumor suppressor genes and provide clues for discovering tumor suppressor genes.Methods Twelve polymorphic microsatellite markers on chromosome 1p36 in 12 cases of glioblastomas were analyzed to detect LOH by PCR based techniques.Results 91.7% informative cases of Glioblastomas displayed LOH on 1p36.The most frequent LOH were observed at loci from D1S214 to D1S2666 on 1p36.Conclusion The highly frequent LOH was observed on chromosome 1p36 in human Glioblastomas.The results of this study indicate that the chromosomal regions at loci from D1S214 to D1S2666 on 1p36 may contain tumor suppressor genes associated with the origin of Glioblastomas.

Key concepts: Loss of heterozygosity, Biology, Suppressor, Microsatellite, Chromosome, Tumor suppressor gene, Gene, Genetics

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