Effect of Chai Shao Liujunzi Decoction Combined with Entecavir for the Treatment of Chronic Hepatitis B:An Observation of 30 Cases

Objective To observe the therapeutic effect of Chai Shao Liujunzi Decoction (CSLD)combined with entecavir for the treatment of chronic hepatitis B (CHB)patients with hepatitis B e antigen (HBeAg)positive which were differentiated as liver stagnation and spleen deficiency.Methods Sixty qualified patients were equally randomized into 2 groups:the control group received entecavir,and the treatment group received CSLD combined with entecavir.After treatment for 3 months,6 months and one year,the DNA quantification of hepatitis B virus (HBV),normalization rate of alanine aminotransferase (ALT),and rate of HBeAg turning negative were observed.Results The decrease of HBV-DNA and the rate of HBV-DNA turning negative in the treatment group did not differ from those in the control group after treatment for 3 months,6 months and one year (P0.05).Normalization rate of ALT was higher in the treatment group than that in the control group (P0.05)after treatment for 3 months,but the difference of ALT normalization rate after treatment for 6 months and one year was insignificant between the two groups (P0.05).The rate of HBeAg turning negative in the treatment group after treatment for one year was higher than that in the control group(P0.05);and the total effective rate on relieving poor appetite,poor-quality sleep,pain in hypochondrium,and abdominal distention was higher in the treatment group than that in the control group (P0.05 or P0.01).Conclusion CSLD combined with entecavir is effective for promoting the recovery of hepatic function,increasing the rate of HBeAg turning negative,and relieving clinical symptoms of patients with chronic hepatitis B.