Meta-analysis of Ondansetron and Ondansetron combined with Dexamethasone for preventing postoperative nausea and vomiting after abdominal surgery

Objective To evaluate the efficacy of Ondansetron combined with Dexamethasone for preventing postoperative nausea and vomiting after abdominal surgery.Methods PubMed,CNKI and Wanfang electronic databases were searched to collected randomized controlled trials(RCT) that were interfere in Ondansetron or Ondansetron combined with Dexamethasone in controlling postoperative nausea and vomiting,Ondansetron was taken as control group,Ondansetron combined with Dexamethasone was taken as test group,The efficacy of Ondansetron combined with Dexamethasone for preventing postoperative nausea and vomiting after abdominal surgery with Meta-analysis was evaluated.Results 11 RCT and 1 021 patients with abdominal surgery were included.There was 509 cases in test groups and 512 cases in control group,Meta analysis showed that the test group was better than the control group in improving the incidence of the total postoperative nausea and vomiting(P 0.05),the overall efficacy of OR and 95%CI of the total postoperative nausea and vomiting was 2.73(1.71,4.34) and 3.20(1.86,4.92).Conclusion Ondansetron combined with Dexamethasone can improve postoperative nausea and vomiting after abdominal surgery.However,more scientific and standardized,high quality,large sample,long-term follow-up of the study is still needed for evaluating safety and efficacy of Ondansetron combined with Dexamethasone for preventing postoperative nausea and vomiting after abdominal surgery