Therapeutic efficacy of bailing capsule combined with pancreatic kininogenase in the treament of early diabetic nephropathy

Objective To observe the therapeutic efficacy of bailing capsule combined with pancreatic kininogenase (PK) in the treatment of early diabetic nephropathy (EDN), and the changes of urinary micro-albumin. Methods Fifty cases of EDN were randomly divided into two groups. On the bases of routine therapy, the comparison group took PK 240 U, 3 times a day orally. On the basis of the comparison group, the combined treatment group took bailing capsule 1.0g, 3 times a day orally. The changes of 24 h urinary albumin excretion rate (UAER) in the com- bined treatment group and the comparison group were observed before and after 12 weeks or 6 months of treatment. Results The 24h UAER of the two groups were all decreased (P0.05) after 12 weeks; after 6 months, the 24 h UAER of the comparison group were decreased (P0.05), and that of the combined treatment group decreased more significantly (P 0.01); there was significant difference between the two groups after 12 weeks or 6 months of treatment (P0.05). Conclusion Bailing capsule combined with PK could significantly reduced urinary micro-albumin excretion of EDN patients and effectively delay the progress of DN.