Therapeutic effect of gink gobioba extract on diabetic cardiomyopathy induced by SZT and ISO in rats

Objective To investigate the therapeutic effect of gink gobioba extract(GBE) on diabetic cardiomyopathy(DCM) induced by streptozotocin(SZT) and isoprenaline(ISO) in rats.Methods 20 male Wistar rats were randomly divided into normal control group(n=5),model group(n=5),positive control group(n=5),and treatment group(n=5).The rats in normal control group were given nothing and the other rats were given STZ and ISO to construct DCM rat models.The rats in model group were given saline and the rats in positive control group and treatment group were given benazepril and GBE,respectively.The body weight,blood sugar level,serum AST and LDH levels,expression level of TGF-β1 protein,and morphology of myocardium of rats in various groups were observed.Results 1 and 2 weeks after treatment,the body weight and blood sugar level of the rats in model group were lower than those in normal control group(P0.05).The body weights and blood sugar levels of the rats in positive control and treatment group were lower than those in normal control group(P0.05).The levels of AST,LDH,and TGF-β1 in model group were higher than those in normal group(P0.05);and the levels of AST,LDH,and TGF-β1 in positive control and treatment group were higher than those in model group(P0.05).The myocardial cells of the rats in normal control group had no swelling.The cells in model group showed clear boundaries and more scattered necrosis,and there were lots of fibroblasts and some collagen fibers in focal necrosis.The myocardial cells of the rats in treatment group had smaller focal necrosis and lower fibrosis.Conclusion GBE can alleviate myocardial injury induced by STZ plus ISO of rats.