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Effect of glutamine on the acute liver injury by Galn/LPS

Lei Yin

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Abstract

Objective To investigate the effect of glutamine on acute liver injury by Galn/LPS. Methods The acute liver injury model was established by Galn/LPS.Pretreatment with 3.5% glutamine solution by intraperitoneal at the dose of 1 g/kg weight.Male mice were treated with LPS plus D-galactosamine. Then blood removed from the vena was analyzed for ALT,and liver tissue was analyzed for the density of MDA,GSH and TNF-α. Results Pretreatment with glutamine could abrogate the high levels of plasma ALT activity,the density of TNF-α and MDA in liver by Galn/LPS,and maintain the density of GSH. Conclusion Glutamine can maintain the level of GSH in liver tissue,regulate the redox state,and prevent liver injury induced by Galn/LPS.

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What this paper is about

Objective To investigate the effect of glutamine on acute liver injury by Galn/LPS. Methods The acute liver injury model was established by Galn/LPS.Pretreatment with 3.5% glutamine solution by intraperitoneal at the dose of 1 g/kg weight.Male mice were treated with LPS plus D-galactosamine. Then blood removed from the vena was analyzed for ALT,and liver tissue was analyzed for the density of MDA,GSH and TNF-α. Results Pretreatment with glutamine could abrogate the high levels of plasma ALT activity,the density of TNF-α and MDA in liver by Galn/LPS,and maintain the density of GSH. Conclusion Glutamine can maintain the level of GSH in liver tissue,regulate the redox state,and prevent liver injury induced by Galn/LPS.

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Available abstract

Objective To investigate the effect of glutamine on acute liver injury by Galn/LPS. Methods The acute liver injury model was established by Galn/LPS.Pretreatment with 3.5% glutamine solution by intraperitoneal at the dose of 1 g/kg weight.Male mice were treated with LPS plus D-galactosamine. Then blood removed from the vena was analyzed for ALT,and liver tissue was analyzed for the density of MDA,GSH and TNF-α. Results Pretreatment with glutamine could abrogate the high levels of plasma ALT activity,the density of TNF-α and MDA in liver by Galn/LPS,and maintain the density of GSH. Conclusion Glutamine can maintain the level of GSH in liver tissue,regulate the redox state,and prevent liver injury induced by Galn/LPS.

Key concepts: Glutamine, Liver injury, Glutathione, Liver tissue, Intraperitoneal injection, Galactosamine, Pharmacology, Tumor necrosis factor alpha

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