CHANGES AND SIGNIFICANE OF SERUM VEGF AND MMP-2 LEVEL OF COLORECTAL CANCER PATIENTS

Objective:To investigate the changes and significance of the vascular endothelial growth factor(VEGF)and matrix metalloproteinase-2(MMP-2) level in serum of colorectal cancer patients.Methods:Double antibody sandwich method was used to detect the serum VEGF and MMP-2 level of 72 colorectal cancer patients(before operation,3 months and1 year after operation),30 colorectal adenomas patients and healthy controls.Results:The serum VEGF and MMP-2 level of colorectal cancer patients before operation were obviously higher than that of colorectal adenomas patients and healthy controls(P0.05);3 months after operation,the serum VEGF and MMP-2 level of colorectal cancer patients were significantly lower than that before operation(P0.05),and had no statistical significance compared with healthy controls(P0.05).The serum VEGF and MMP-2 level of colorectal cancer patients were not related to age,sex,histological type,gross classification and tumour location(P0.05);but related to Dukes stage,differentiated degree,lymph node metastasis,depth of infiltration and tumour size(P0.05).1 year after operation,the serum VEGF and MMP-2 level of relapsed patients were obviously higher than that of no relapsed patients(P0.05).Conclusions:The serum VEGF and MMP-2 level may play important role in early diagnosis,severity assessment and prognostic evaluation of colorectal cancer.