Different dose of sufentanil for postoperative patient-controlled intravenous analgesia after resection of liver cancer

Objective To compare the clinic effect and safety of different dose of sufentanil for postoperative patient-controlled intravenous analgesia after resection of liver cancer.Methods Sixty patients aged from 40 to 55 years weighing 45~75 kg scheduled for resection of liver cancer under general anesthesia were divided into 3 groups(n=20 each): group S1 receiving patient-controlled intravenous analgesia with sufentanil 0.02 μg/(kg·h);group S2 sufentanil 0.04 μg/(kg·h) and group S3 sufentanil 0.06 μg/(kg·h).Visual analogue scale(VAS),VAFS,sedation scores,vital signs(MAP,HR,RR,SpO2)were assessed after 4,12,24 and 48 hours of of postoperative analgesia.The scores of satisfaction of postoperative analgesia and the adverse reations including nausea,emesis,pruritus and resperitory inhibition were recorded.Results After 4,12 and 24 hours of postoperative analgesia,VAS and VAFS scores were higher in group S1 than group S2 and group S3(P0.05).After 4 hours of postoperative analgesia,VAFS scores were higher in group S2 than group S3(P0.05).After 4 and 12 hours of postoperativea nalgesia,White scores were higher in group S3 than group S1 and group S2(P0.05).After 4 hours of postoperative analgesia,RR was slower in group S3 than group S1(P0.05).The scores of satisfaction of postoperative analgesia were higher in group S1 than group S2 and group S3(P0.05).The incidence of adverse events including the adverse reactions(nausea,emesis,pruritus) was lower.Conclusion Sufentanil 0.04 μg/(kg·h) for postoperative analgesia after resection of liver cancer provides better analgesia effect,and the adverse reaction is fewer.