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2003•Chinese Journal of Neurosurgical Disease ResearchRequires access

Expression of PTEN and Cyclin D1 in gliomas and its significance

Weizhong Yang

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Abstract

Objective To explore the significance of PTEN and Cyclin D1 expression in human gliomas. Methods Immunohistochemistry combined with computer assisted image analysis system was carried out to examine the expression of Cyclin D1 and PTEN in 80 specimens of gliomas. Results Expression of PTEN protein was in 63.8% in 80 gliomas, and the positive rate in gliomas with low grade was much higher than that with high grade. The expression of Cyclin D1 in WHO grades of gliomas was of significant difference. A significant correlation was observed between the expression of PTEN protein and Cyclin D1 in gliomas. Conclusion PTEN protein may play an important rule in regulation of cell cycle and cell proliferation in human gliomas.

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What this paper is about

Objective To explore the significance of PTEN and Cyclin D1 expression in human gliomas. Methods Immunohistochemistry combined with computer assisted image analysis system was carried out to examine the expression of Cyclin D1 and PTEN in 80 specimens of gliomas. Results Expression of PTEN protein was in 63.8% in 80 gliomas, and the positive rate in gliomas with low grade was much higher than that with high grade. The expression of Cyclin D1 in WHO grades of gliomas was of significant difference. A significant correlation was observed between the expression of PTEN protein and Cyclin D1 in gliomas. Conclusion PTEN protein may play an important rule in regulation of cell cycle and cell proliferation in human gliomas.

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Available abstract

Objective To explore the significance of PTEN and Cyclin D1 expression in human gliomas. Methods Immunohistochemistry combined with computer assisted image analysis system was carried out to examine the expression of Cyclin D1 and PTEN in 80 specimens of gliomas. Results Expression of PTEN protein was in 63.8% in 80 gliomas, and the positive rate in gliomas with low grade was much higher than that with high grade. The expression of Cyclin D1 in WHO grades of gliomas was of significant difference. A significant correlation was observed between the expression of PTEN protein and Cyclin D1 in gliomas. Conclusion PTEN protein may play an important rule in regulation of cell cycle and cell proliferation in human gliomas.

Key concepts: PTEN, Cyclin D1, Immunohistochemistry, Cancer research, Cyclin, Glioma, Cell cycle, Biology

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