The effect observation of different administration mode of ondansetron on preventing nausea and vomiting caused by patient controlled analgesia

Objective To observe the effect of different administration mode of ondansetron on preventing nausea and vomiting caused by patient controlled analgesia.Methods 60 cases orthopaedic patients with elective surgical procedures were randomly divided into three groups of A,B,C,each of 20 cases.3 groups were given conventional anesthesia.A group were given intravenous ondansetron 4mg after operation,and added ondansetron 4mg to PCEA pump at the same time;B group added ondansetron 8mg to PCEA pump after operation;C group were given intravenous ondansetron 8mg after operation.Observed the nausea and vomiting occurrence rate 24h after operation,and classified their degree.Results The nausea and vomiting occurrence rate of A,B group were lower than that of C group,the diffenence was statistically significant(P0.05),and there was no difference between A group and B group.The nausea and vomiting degree of A group were lighter than that of B group,B group were lighter than C group,the diffenence was statistically significant(P0.05).Conclusion Ondansetron can effectively preventing nausea and vomiting after operation,the therapy of intravenously combine with PCEA pump application of ondansetron 4mg can get the best effect.