A clinical study on the influence of postoperative nausea and vomitting by different administrations of Ondansetron

Objective To study whether preoperative blocking 5-HT receptor by Ondansetron can delay postoperative nausea and vomiting;and to find the best administration of Ondansetron.Methods Randomly select 100 patients having operations on abdominal region within four hours,and divide them into four groups: Group Ⅰ: Ondansetron 8 mg was given pre-operation induction;Group Ⅱ: Ondansetron 4 mg was given pre-operation induction and the other 4 mg was given postoperatively;Group Ⅲ: Ondansetron 8 mg was given postoperatively;Group Ⅳ:the blank group.Deplete the interference as far as possible.The patients of each group all used patient-controlled analgesia(PCA) after operation.Record the nausea and vomiting degree of the patients at 1、6、12、24 h after operation,and do statistical treatment of the consequence to the differences of the results were treated by statistics.Results There was significant deviation between Group Ⅰ,Group Ⅱ,Group Ⅲ and the blank group,it had statistical significance.It proved that Ondansetron could delay the occurrence of postoperative nausea and vomiting.However there was no significant deviation among Group Ⅰ,Group Ⅱ,and Group Ⅲ,it had no statistical significance.It proved that preoperative blocking 5-HT receptor by Ondansetron 8 mg or 4 mg could not delay the occurrence of postoperative nausea and vomiting.Conclusion Preoperative blocking 5-HT receptor by Ondansetron 8 mg or 4 mg can not delay the occurrence of postoperative nausea and vomiting for patients having operation on abdominal region within four hours.It also proves that Ondansetron 8 mg can be used both preoperatively or postoperatively or preoperatively plus postoperatively in order to prevent postoperative nausea and vomiting.