Efficacy of intravenous ondansetron for preventing nausea and vomiting caused by different reasons during or post-cesarean section

Objective To observe the efficacy of intravenous 5-hydroxytryptamine 3 receptor antagonist in the prevention of nausea and vomiting while and after cesarean section(CS). Methods A total of 280 pregnant women with American Society of Anesthesiologists(ASA) Physical Status Ⅰ-Ⅱ who underwent emergency and elective CS under combined spinal-epidural anesthesia(CSEA) were randomly divided into two groups(n=140): in clamping the umbilical vein immediately intravenous ondansetron 8 mg(ondansetron group) or 0.9% normal saline 4 ml(control group) were intravenously infused, respectively. The episodes of nausea and vomiting intraoperatively and postoperatively were observed. Results In ondansetron group, the incidence of intra- and post-operative nausea and vomiting reduced significantly compared with the control group, and the incidences of intraoperative severe nausea and vomiting in full stomach patients of ondansetron group were 6.5%, which were significantly lower than that in control group. The incidences of postoperative moderate and severe nausea and vomiting patients who using PCEA of ondansetron were significantly lower than that in control group(P0.05). Conclusion Ondansetron has better treatment for intra- and post-operative nausea and vomiting caused by full stomach and PCEA.