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2007•Carcinogenesis,Teratogenesis and MutagenesisRequires access

Acute Toxicity and Genotoxicity Tests of Selenium-enriched Probiotics

Kehe Huang

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Abstract

BACKGROUND AIM: To study the acute toxicity and genotoxicity of selenium-enriched probiotics. MATERIALS AND METHODS: Acute toxicity test of mice,Ames test,micronucleus test of bone marrow PCE cell in mice, sperm abnormality test of mice were used. RESULTS: The oral acute toxicity study revealed that the LD50 of selenium-enriched probiotics was 18.49 g/kg in mice. The results of genotoxicity tests were all negative, including Ames test, micronucleus test and sperm shape abnormality test. CONCLUSION: Selenium-enriched probiotics showed certain toxicity but no genotoxicity in this study. Thus,selenium-enriched probiotics was safe at the daily-recommended dose(50 mg/person/day) and has the potential for development into functional foods.

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BACKGROUND AIM: To study the acute toxicity and genotoxicity of selenium-enriched probiotics. MATERIALS AND METHODS: Acute toxicity test of mice,Ames test,micronucleus test of bone marrow PCE cell in mice, sperm abnormality test of mice were used. RESULTS: The oral acute toxicity study revealed that the LD50 of selenium-enriched probiotics was 18.49 g/kg in mice. The results of genotoxicity tests were all negative, including Ames test, micronucleus test and sperm shape abnormality test. CONCLUSION: Selenium-enriched probiotics showed certain toxicity but no genotoxicity in this study. Thus,selenium-enriched probiotics was safe at the daily-recommended dose(50 mg/person/day) and has the potential for development into functional foods.

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Available abstract

BACKGROUND AIM: To study the acute toxicity and genotoxicity of selenium-enriched probiotics. MATERIALS AND METHODS: Acute toxicity test of mice,Ames test,micronucleus test of bone marrow PCE cell in mice, sperm abnormality test of mice were used. RESULTS: The oral acute toxicity study revealed that the LD50 of selenium-enriched probiotics was 18.49 g/kg in mice. The results of genotoxicity tests were all negative, including Ames test, micronucleus test and sperm shape abnormality test. CONCLUSION: Selenium-enriched probiotics showed certain toxicity but no genotoxicity in this study. Thus,selenium-enriched probiotics was safe at the daily-recommended dose(50 mg/person/day) and has the potential for development into functional foods.

Key concepts: Genotoxicity, Ames test, Micronucleus test, Selenium, Toxicity, Acute toxicity, Micronucleus, Sperm

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