Dynamic Changes and Clinical Significance of Serum MMP-3 and MMP-9 in Patients with Cerebral Infarction

Objective: To investigate the dynamic changes and clinical significance of serum matrix metalloproteinase-3(MMP-3) and matrix metalloproteinase-9(MMP-9) on various stages in patients with cerebral infarction.Methods: 62 cerebral infarction and lacunar infarction patients were divided into the observation group one and the observation group two,while 30 healthy people served as the control group.Serum MMP-3 and MMP-9 levels and the scores of the Clinical Neurological Function Deficient(CNFDS) were measured during the onset 2 to 5 days and 15 days in the observation group and the control group.Results: The levels of serum MMP-9 and MMP-3 during 2 to 5 days of the cerebral infarction were higher than those in the control group(P0.01).The serum MMP-9 levels in the observation group one were significantly higher than those in the observation group two(P0.01).The levels of serum MMP-3 and MMP-9 at the onset 15 days of the observation groups had no significant difference compared with those of the control group.Correlation analysis showed that there was a negative correlation between MMP-9,MMP-3 and prognosis.Conclusion: MMP-3 and MMP-9 may contribute to the pathologic course in the early stage of cerebral infarction.The levels of MMP-3 and MMP-9 are correlated with the clinical course of the disease and prognosis.