Relationship among the level of serum MMP-9 at acutestage of cerebral infarction and the significance in prognosis

Objective To determine and compare the level of serum MMP-9 at acute stage of cerebral infarction and to approach the relationship among the level of serum MMP-9 and the classification of TOAST and the significance in prognosis.Methods 60 patients with cerebral infarction were included in our study,while 20 healthy people served as the control group. The serum specimens were gathered for MMP-9 determination with ELISA on admission,at the 5th and 10th day of onset. All patients were scored according to the American National Institutes of Health stroke scale (NIHSS) on admission and recorded Barthal Index(BI) in the 1st and 6 month of onset.Results (1)The serum level of MMP-9 increased after cerebral infarction,and was significantly higher than those in the control group( P 0.05).There was no significant difference between CE and LAA group ( P 0. 05).MMP-9 in CE and LAA group was significantly higher than those in SA group ( P 0.05) .MMP-9 in SA group decreased to normal level while was still higher in CE and LAA group on the 5th day of onset. On the 10th day MMP-9 in all groups decreased to normal.( 2) There was a positive correlation between MMP-9 within 24 hours of onset and NIHSS( r =0.883, P 0.01).(3)The serum level of MMP-9 in the cases with better prognosis was significantly lower than those with worse prognosis.Conclusions (1)The serum levels of MMP-9 in all groups increased,but the tendency of their variation was not similar;(2)Serum level of MMP-9 was related to NIHSS, can reflect the severity of the state of cerebral the severity of the state of cerebral infarction;(3)The level of serum MMP-9 within 24 hours of onset can predict prognosis of cerebral infarction independently.