The effectiveness of rosuvastatin on hs-CRP and Lp-PLA2 in the serum of patients with acute cerebral infarction

Objective To study the effectiveness of rosuvastatin on high sensitivity C-reactive protein(hs-CRP) and lipoprotein-associated phospholipase A2(Lp-PLA2) in the serum of patients with acute cerebral infarction.Methods Eighty-six patients with acute cerebral infarction were randomly divided into two groups,the conterol group(n=40 cases) and the treatment group(n=46 cases).The patients in the control group were treated through the conventional treatment and the patients in the treatment group were treated through rosuvastatin plus the conventional treatment. Rosuvastatin was used through orally 20 mg once daily.The hs-CRP and Lp-PLA2 were detected before and after treatment.Results The hs-CRP and Lp-PLA2 in serum of patients were decreased after treatment.There was a significant difference between two groups(P0.05).There were not any serious adverse events in the both groups.Conclusion Rosuvastatin can significantly decresse hs-CRP and Lp-PLA2 in the serum of patients with acute erebral infarction.