The Clinical Study of Combined Administration of Milinone and Sodium Nitroprusside on Refractory Heart Failure

Objective:To explore the effect of combined administration of milinone and sodium nitroprusside on refractory heart failure. Methods:90 patients with refractory heart failure was randomized into group A, B, C and 30 cases each, treated by milinone, dobutamine and milinone combined with sodium nitroprusside. NYHA functional classification and echocardiography was conducted before and after the treatment, ejection fraction (EF), cardiac output (CO), stroke volume(SV), cardiac index(CI) and VA/VE were recorded. Results:The total efficiency in group A, B and C was 57%, 47% and 87% .The difference was significantly(P 0.05). The echocardiography results improved in all the three groups (P 0.05, especially in group C, P 0.001). Conclusion:Milinone is a candidate for refractory heart failure, especially for the patients who are not suitable for digitalis and combined with sodium nitroprusside, the clinical effect improves significantly.