The Expression of Brain Natriuretic Peptide(BNP) Homocysteine(HCY) in Patients with Chronic Heart Failure

Objective:To evaluate the concentration of serum brain natriuretic peptide(BNP),Homocysteine(HCY)homocysteine,C-reactive protein in patients with chronic heart failure(CHF).Methods:Our study included 70 patients with chronic heart failure(CHF)(CHF group)and 65 healthy subjects after examination served as healthy control group.CHF group were divided into three subgroups according to NYHA cardiac function classification(abbreviated as heart function Ⅱ,Ⅲ,Ⅳ groups).The levels of BNP、HCYwere measured.Left ventricular end-diastolic diameter(LVEDD)and left ventricular ejection fraction(LVEF)of all patients were determinated by echocardiogram when they were in hospital.Results:① Plasma concentrations of BNP and HCY in CHF group were significantly higher than those in control group before treatment;② Before the treatment the conclusion in different CHF group is that :individuals with higher level of BNP and HCY concentration had higher NYHA cadica function classification;③Correlation analysis indicated that BNP and HCY level were positively correlated with LVEDD,however,were negatively correlate with LVEF.④They were positively correlated with the severity of the disease as well as the occurrence of cardiac events(P0.01).Conclusions:The level of BNP and HCY in CHF group is positive correlated with NYHA cardiac function classification and LVEDD.The level of plasma BNP and HCY elevated in these patients with the increase of NYHA cardiac function classification and lower of LVEDD.They may reflect the cardiac function classification clearly.The level of plasma BNP and HCY were helpful for outcome p rediction.