2012•Shanxi Yike Daxue xuebaoRequires access

Determination of contents of sodium Danshensu in Zhixuantongmai capsule by HPLC

Wang Zengxian

Abstract

Objective To establish a method for determining the content of sodium Danshensu in Zhixuantongmai capsule by HPLC.Methods C18 column(250 mm×4.6 mm,5 μm) was applied with the mobile phase of methanol-1% acetic acid solution(8∶ 92) at UV detection wavelength of 280 nm.The content of sodium Danshensu in Zhixuantongmai capsule was determined by HPLC method.The calibration curve method was used to calculate the content of sodium Danshensu.Results Sodium Danshensu showed a good linear relationship in the range of 0.101 8-0.509 μg,and the equation was y=362.63x-15.448(r=0.999 8).The average recovery was 96.18% and RSD was 2.76%(n= 6).Conclusion The established method is sensitive and repeatable,and can effectively control the content of sodium Danshensu in Zhixuantongmai capsule.

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Key concepts: Capsule, High-performance liquid chromatography, Chromatography, Sodium, Chemistry, Content determination, Calibration curve, Acetic acid