A clinical study on combination of captopril and spironolactone in aged patients with congestive heart failure and ventricular arrhythmia

Objective: To study on the cli n ical effect and safety of combination of captopril and spironolactone in aged pa tients with congestive heart failure (CHF) and ventricular arrhythmia. Method: Two hundred aged patients with CHF and ventricular arrhythmia were enrolled in this clinical study. Observation of the alternation of heart function and the clinical effects was made after using captopril and s pironolactone. Result: Ventricular premature beat of 98% cases reduced ob viously. Partial ventricular tachycardia or R on T phenomena of some patients disappeard. Furthermore, the heart function of 96% patients improved to over 1 class (by NYHA) and clinical signs changed better obviously. Potassium ions of all cases kept stable within normal limits and nobody got hyperpotassemia. Conclusion: The combination of captopril and spironolacton e is absolutely reliable and safe for the aged patients with CHF and worth popul arizing.