UROKINASE COMBINED WITH BENAZEPRIL IN TREATMENT OF IGA NEPHROPATHY

[Objective]To explore the use of urokinase combined with benazepril in treatment of IgA nephropathy.[Methods]140 cases of IgA nephropathy patients were randomly divided into control group(n = 70)and observation group(70 cases),the observation group patients with urokinase plus benazepril combined therapy,the control group only benazepril.We compared the therapeutic effects of two groups.[Results]After 6 courses of treatment,the observation group in the volume of urine protein and Scr levels compared with before treatment was significantly lower,and the level of Alb and Ccr were significantly increased(P﹤0.05,0.01),and the improved level were significantly better than the control group(P﹤0.05);The total efficiency of the observation group was 74.3%(52/70),which was significantly higher than that of control group(51.4%,36/70),the difference was statistically significant(χ2 = 7.83,P﹤0.01).[Conclusion]The urokinase combined with benazepril in treatment of IgA nephropathy curative effect,which can improve the renal function,and was better than simply using benazepril.This method is worthy of further clinical application.