2012•Liaoning zhongyi zazhiRequires access
Research on Dose-effect Relationship of Herbs-partitioned Moxibustion for Cold Accumulation Syndrome of Dysmenorrhea and Its Influence on Prostaglandin
Le Ji
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Abstract
Objective:To observe the clinical efficacy of dose-effect relationship of herbs-partitioned moxibustion on Shenque(RN8)for cold accumulation syndrome of dysmenorrhea and its influence on PGF2α and PGE2.Methods:120 cases of moderate cold accumulation syndrome of primary dysmenorrhea were randomly divided into four groups according to the SPSS11.0 statistics software.Another 30 cases were the normal control group.Among them,the observation group A,B and C were treated by herbs-partitioned moxibustion on RN8 and the medicine group was treated by western medicine.Before treatment and after 3 courses,the patients should take the PGF2α and PGE2 tests in 48 hours when the menstruation period.Results:Group A:the total effective rate was 96.7%;group B:the total effective rate was 93.3%;group C:the total effective rate was 90.0%.The medicine group:the total effective rate was 76.7%.Compared with the PGF2α and PGE2 score before and after treatment of observation A,B and C groups(P0.01),there was remarkably statistical significance;compared with the PGF2α and PGE2 score before and after treatment of the control group(P0.05),there was statistics significance.Compared with the PGF2α and PGE2 score after treatment between observation A and B groups,observation B and C groups,observation C and the medicine groups(P0.05),there was statistics significance;Compared the PGF2α and PGE2 score after treatment between observation A and C groups,observation A and the medicine groups,observation B and the medicine groups(P0.01),there was remarkably statistical significance.Conclusion:The clinical efficacy of primary dysmenorrhea treated by herbs-partitioned moxibustion was better than western medicine and large quantity of moxibustion was better than the small one.And the method is convenient,secure,and without adverse reactions.The mechanism has relationship with regulating prostaglandin,which means reducing PGF2α in peripheral blood and raising PGE2 during menstruation.