Establishment of TSH cut-off point for neonatal congenital hypothyroidism screening in Zhuzhou

Objective: To establish the TSH cut-off point of neonatal congenital hypothyroidism(CH) in Zhuzhou.Methods: 47066 dried blood Samples were collected from more than120 delivery organizations for CH screening.The TSH value on the filter paper was measured by DELFIA method.Finally,the positive newborns were recalled for further confirming.Results: when the cut-off point is 9μIU/mL,the sensitivity is 100%,specificity is 99.53%,and no positive newborns was missed;while think about the 99%confidence interval according to percentile method,the cut-off point should be 8.52 μIU/mL;and nine High TSH hematic disease patients were found,whose lowest TSH concentration was 8.61μIU/mL.Conclusion: In order to improve the effect of neonatal congenital hypothyroidism screening,and enforce the recalling of High TSH hematic disease patients,The TSH cut-off point was adjust to 8.5μIU/mL.