The therapeutic effect of nimodipine in treatment of severe traumatic brain injuries with subarachoid hemorrhage

Objective To observe the therapeutic effect of nimodipine in treatment of severe cranio-cerebral trauma with subarachoid hemorrhage (SAH). Methods Sixty patients with severe cranio-cerebral injury complicated by SAH (GCS 3-8) were divided randomly into two groups. In nimodipine group 40 mg nimodipine was injected intravenously by micro-pump for ten days, then 60mg by oral administration QID×15 days. In control group patients receives the same treatment measures but no nimodipine was given. Intracranial pressure and GCS were closely observed, GOS and complication were measured 6 months later. Results The GCS of nimodipine group from the first 4 days after treatment was significantly higher than that of the control group (P0.05); the intracranial pressure of the nimodipine group was slightly higher than the control group in the first 3 days, but there was no significant difference (P0.05). the incidences of cerebral infarction and hydrocephalus in the nimodipine group were significantly less than that of control group(P0.05), the incidence of delayed bleeding slightly more than the control group, but there was no significant difference (P0.05). The GOS of the nimodipine group after six months was significantly higher than the control group (P0.01). Conclusion Nimodipine has definitive therapeuric effect for severe cranio-cerebral trauma with SAH.