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2008•Chinese Archives of Otolaryngology-head and Neck SurgeryRequires access

Expression and correlation of COX-2 and VEGF-C in nasopharyngeal carcinoma

Tao Wang

Open publisher page 1 citations

Abstract

OBJECTIVE To investigate vascular endothelial growth factor-C (VEGF-C) and cyclooxyegense-2(COX-2) expression in nasopharyngeal carcinoma. METHODS The expression of COX-2 and VEGF-C were stained respectively in nasopharyngeal carcinoma tissues of 45 patients using immunohistochemical method,and were analyzed with clinical data. RESULTS The positive expression rates of COX-2 and VEGF-C were 68.9 % and 53.3 % respectively in nasopharyngeal carcinoma tissue. The expression of COX-2 was positively correlated with VEGF-C (r=0.334,P0.05). The expression of both COX-2 and VEGF-C were correlated with clinical stage and lymph node metastasis(P0.05). CONCLUSION COX-2 and VEGF-C were highly expressed in nasopharyngeal carcinoma. The coexpression of COX-2 and VEGF-C may play an important role in the carcinogenesis and development of nasopharyngeal carcinoma,and they may promote lymph node metastasis of nasopharyngeal carcinoma.

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OBJECTIVE To investigate vascular endothelial growth factor-C (VEGF-C) and cyclooxyegense-2(COX-2) expression in nasopharyngeal carcinoma. METHODS The expression of COX-2 and VEGF-C were stained respectively in nasopharyngeal carcinoma tissues of 45 patients using immunohistochemical method,and were analyzed with clinical data. RESULTS The positive expression rates of COX-2 and VEGF-C were 68.9 % and 53.3 % respectively in nasopharyngeal carcinoma tissue. The expression of COX-2 was positively correlated with VEGF-C (r=0.334,P0.05). The expression of both COX-2 and VEGF-C were correlated with clinical stage and lymph node metastasis(P0.05). CONCLUSION COX-2 and VEGF-C were highly expressed in nasopharyngeal carcinoma. The coexpression of COX-2 and VEGF-C may play an important role in the carcinogenesis and development of nasopharyngeal carcinoma,and they may promote lymph node metastasis of nasopharyngeal carcinoma.

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Available abstract

OBJECTIVE To investigate vascular endothelial growth factor-C (VEGF-C) and cyclooxyegense-2(COX-2) expression in nasopharyngeal carcinoma. METHODS The expression of COX-2 and VEGF-C were stained respectively in nasopharyngeal carcinoma tissues of 45 patients using immunohistochemical method,and were analyzed with clinical data. RESULTS The positive expression rates of COX-2 and VEGF-C were 68.9 % and 53.3 % respectively in nasopharyngeal carcinoma tissue. The expression of COX-2 was positively correlated with VEGF-C (r=0.334,P0.05). The expression of both COX-2 and VEGF-C were correlated with clinical stage and lymph node metastasis(P0.05). CONCLUSION COX-2 and VEGF-C were highly expressed in nasopharyngeal carcinoma. The coexpression of COX-2 and VEGF-C may play an important role in the carcinogenesis and development of nasopharyngeal carcinoma,and they may promote lymph node metastasis of nasopharyngeal carcinoma.

Key concepts: Nasopharyngeal carcinoma, Immunohistochemistry, VEGF receptors, Lymph node metastasis, Medicine, Vascular endothelial growth factor, Stage (stratigraphy), Carcinogenesis

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