Expression of VEGF and Survivin in Nasopharyngeal Carcinoma

Objective To explore the expression of vascular endothelial growth factor(VEGF) and Survivin in nasopharyngeal carcinoma.Methods Immunohistochemical method staining for the paraffin sections(SP method) were used to assess the expression of VECF and Survivin expression in 80 cases of nasopharyngeal carcinoma tissues and 24 cases of nasopharyngeal chronic inflammation tissues.Results The overexpression rate of VEGF protein was 75.76% (61/80) in nasopharyngeal carcinoma tissues,and 25.00% (6/80) in nasopharyngeal chronic inflammation tissues(P<0.01) ;The overexpression rate of Survivin protein was 67.50% (54/80) in nasopharyngeal carcinoma tissues,and 16.67% (4/80) in nasopharyngeal chronic inflammation tissues(P<0.01).The expression of VEGF was related to TNM stage,T stage,lymph node metastasis and distant metastasis (P<0.05) ,and there was a close relation between the expression of Survivin and TNM stage,T stage,lymph node metastasis and distant metastasis (P<0.05).Conclusion Detecting the expression levels of VEGF and Survivin proteins simultaneously in nasopharyngeal carcinoma had certain reference value for judging biological behavior and evaluating prognosis of patients with nasopharyngeal carcinoma. Key words: Vascular endothelial growth factor; Survivin; nasopharyngeal Carcinoma; Immunohistochemical method