Expression and clinical significance of P120ctn,VEGF-C in human nasopharyngeal carcinoma

Objective To investigate the expression and significance of P120 catenin(P120ctn),vascular endothelial growth factor-C(VEGF-C) in human nasopharyngeal carcinoma.Methods Using immuno-histochemical technique to examine the expression of P120ctn,VEGF-C in 56 nasopharyngeal carcinoma cases(nasopharyngeal carcinoma group)and 15 normal mucous membrane of nasopharynx cases(normal group),and the relations between P120ctn,VEGF-C and clinicopathological features were analyzed.Results P120ctn abnormal rate of the nasopharyngeal carcinoma group and normal group were 67.86%,6.67%,and VEGF-C positive expression rate were 83.92%、26.6%,both P0.05;the abnormal rate of P120ctn was correlated with the pathomorphological classification,TNM stage,cervical lymph node metastasis of nasopharyngeal carcinoma,and the positive rate of VEGF-C was correlated with the TNM stage and cervical lymph node metastasis of nasopharyngeal carcinoma;The expression of VEGF-C was positive correlated with P120ctn.Conclusions The abnormal expressions of P120ctn and VEGF-C in nasopharyngeal carcinoma usually occurred during the process of development and progression,which might be related with invasion and metastasis,and might be used as important signal of biological features and prognosis.