2002•Chinese Journal of Current Advances in General SurgeryRequires access

Expression of P53 protein and its clinical significance in gallbladder carcinoma

Wang Bai

Abstract

Objective:To study the expression of P53 protein and its clinical significance in gallbladder carcinoma.Methods:The expression of P53 protein was examined in tissues of gallbladder cancer and cholecystitis by S P immunohistochemistry.Results:The positive rate of P53 protein in gallbladder carcinoma was 71.7%(38/ 53) which was significantly higher than 0(0/ 12)in cholecystitis(P0.01).The expression of P53 protein in gallbladder carcinoma was associated with the histological differentiation of tumor cell and Nevin stage of gallbladder cancer(P0.05).Conclusion:P53 protein play an important role in the occurrence and development of gallbladder cancer and it could act as an important prognostic indicator in gallbladder carcinoma.

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Key concepts: Gallbladder, Immunohistochemistry, Gallbladder cancer, Cholecystitis, Carcinoma, Clinical significance, Medicine, P53 protein