Expressions and the clinical significances of Cyclin D1,MMP-7 and PRB2/p130 in adenoid cystic carcinoma of salivary gland

Purpose To investigate the expression of Cyclin D1,MMP-7 and PRB2/p130 in adenoid cystic carcinoma of salivary gland and their correlation with the biological behavior.Methods The protein expressions of Cyclin D1,MMP-7 and PRB2/p130 in 46 cases of adenoid cystic carcinoma and 30 cases of normal salivary gland were detected with SP immunohistochemical method.Results The positive rate of Cyclin D1,MMP-7 and PRB2/p130 was 71.74%,67.39% and 63.04% respectively.The expression of Cyclin D1 and PRB2/p130 protein were related to pathologic classification(P0.05).The expression of MMP-7 was not related to pathologic classification(P0.05).There was a significant difference in the Cyclin D1,MMP-7 and PRB2/p130 expression rate between with and without recurrence groups(P0.05).There were significant negative correlations between Cyclin D1 and PRB2/p130 protein expression.There were significant positive correlations between Cyclin D1 and MMP-7 protein expression.Conclusion The abnormal expression of Cyclin D1,MMP-7 and PRB2/p130 protein have the important role in the development and recurrence of adenoid cystic carcinoma of salivary gland.The combined detection of multiple biomarkers may be useful for determining the prognosis of patients.