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[Expression and significance of cyclin D1 in human adenoid cystic carcinoma].

Wei He, Xuanping Cao, Longjiang Li

Abstract

OBJECTIVE: To observe the expression of cyclin D1 in human adnoid cystic carcinoma and its correlation with clinical characters. METHODS: The expression of cycline D1 was evaluated with immunohistochemical method in forty-one cases of human adnoid cystic carcinoma, 15 cases of PA and 12 cases of normal salivary gland tissue. RESULTS: The expression of cyclin D1 in normal tissue was negative, significantly different from PA and ACC (P < 0.05). The expression level of PA was significantly lower than ACC (P < 0.05). High expression of cyclin D1 was correlated with clinical stage and histological classification (P < 0.05), but not with sex, age, tumor site, recurrence, metastasis. CONCLUSION: High expression of cyclin D1 promotes the formation and development of ACC.

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Key concepts: Adenoid cystic carcinoma, Cyclin D1, Immunohistochemistry, Pathology, Stage (stratigraphy), Cyclin, Clinical significance, Metastasis